High-fat diet caused an impairment of lipolysis in epididymal adipose tissue, which was partially restored by adiponectin treatment. Long-term globular adiponectin administration was able to improve pathways of insulin signalling and lipid storage in adipose tissue of high-fat diet-fed rats, contributing to a better metabolic profile. We provide here a detailed and comprehensive analysis of skeletal muscle metabolomic profiles in response to adiponectin in adiponectin knockout AdKO mice after high-fat diet HFD feeding. Hyperinsulinemic-euglycemic clamp studies showed that adiponectin administration corrected HFD-induced defects in post/basal insulin stimulated R d and.
Adiponectin Corrects High-Fat Diet-Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis. Lookup NU authors: Dr Nick Morris. Downloads. Full text for this publication is not currently held within this repository. Alternative. We provide here a detailed and comprehensive analysis of skeletal muscle metabolomic profiles in response to adiponectin in adiponectin knockout AdKO mice after high-fat-diet HFD feeding. Hyperinsulinemic-euglycemic clamp studies showed that adiponectin administration corrected HFD-induced defects in post/basal insulin stimulated Rd and insulin signaling in skeletal muscle. This article is from Diabetes, volume 62.AbstractWe provide here a detailed and comprehensive analysis of skeletal muscle metabolomic profiles in response to. Adiponectin Corrects High-Fat Diet–Induced Disturbances in Muscle Metabolomic Profile and Whole-Body Glucose Homeostasis Diabetes, Mar 2013 Ying Liu, Subat Turdi, Taesik Park, Nicholas J. Morris, Yves Deshaies, Aimin Xu, Gary Sweeney.
21/02/2019 · Replenishment of adiponectin in ad-KO mice corrects high fat diet-induced cardiac insulin resistance. Insulin-stimulated signaling Akt T308 and S473 was examined in the heart of Ad-KO mice fed chow or HFD for 6 weeks and in the latter group also after administration of Ad for an additional 2 weeks Fig. 1a. 12/11/2012 · It has been approved by the FDA in January 2010 for treatment of hyperglycemia in patients with T2DM. In previous studies, we have demonstrated that exenatide, a GLP-1 receptor agonist, could increase adiponectin Acrp30 expression in high fat diet HFD induced insulin resistant rats and in rats fed a normal chow diet. 01/04/2019 · Hence, we investigated whether exercise could improve the FGF21-adiponectin axis impairment and ameliorate disturbed glucose metabolism in diet-induced obese mice. METHODS: Eight-week-old C57BL/6J mice were randomly assigned to three groups: low-fat diet control group, high-fat diet group and high-fat diet plus exercise group. 05/12/2017 · To test the potential efficacy of recombinant macrophage inhibitory cytokine-1 MIC-1/GDF15 as an obesity therapeutic. Male C57BL/6 J mice, either fed on normal chow or high-fat diet for 16 weeks to induce diet-induced obesity, were infused with either recombinant MIC-1/GDF15 or vehicle for 34 days by osmotic minipump. During the experimental.
01/09/2008 · Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice - Volume 100 Issue 3 - S. Fukumitsu, K. Aida, N. Ueno, S. Ozawa, Y. Takahashi, M. Kobori. Replenishment of adiponectin in ad-KO mice corrects high fat diet-induced cardiac insulin resistance Insulin-stimulated signaling Akt T308 and S473 was ex-amined in the heart of Ad-KO mice fed chow or HFD for 6weeks and in the latter group also after administration.
19/12/2016 · The replenishment of adiponectin reversed some of the high-fat diet–induced insulin resistance, but certainly not all of it. The high-fat diet induced skeletal muscle triacylglycerol TAG and diacylglycerol DAG accumulation, and both of these accumulations were reversed by adiponectin. 22/03/2017 · Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice. Nat. Commun. 8, 14859 doi: 10.1038/ncomms14859 2017. Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Adiponectin APN, an adipose-derived adipokine, offers cardioprotective effects although the precise mechanism of action remains unclear. This study was designed to examine the role of APN in high fat diet-induced obesity and cardiac pathology. 23/07/2019 · Using high-fat diet HFD-fed mice, we further showed that the adrenergic stimulation was abolished in obesity/type 2 diabetes due to reduced abundance of both β 3 ARs and Epac1 22. We have also verified the cAMP/Epac-dependent stimulation of adiponectin release in.
01/07/2015 · Almost all of these studies were performed in young mice and very few studies have examined changes in aged Ad-KO mice. However, one very recent study has shown that high-fat diet induced more cardiac endoplasmic reticulum ER stress in 11-month-old Ad-KO vs wild-type wt mice. induced by abdominal aortic banding. After sur-gery, wild type and adiponectin-deﬁ cient mice were fed a high-fat diet for 8 weeks 45 % energy from fat vs. 10 %. In wild type mice the high-fat diet increased fat and whole body mass, which corresponded with elevated circulating insulin and leptin and a decrease the glucose / insulin ratio. Data demonstrated that the majority of high fat diet-induced changes in metabolite profiles from multiple metabolic pathways were normalized upon adiponectin supplementation. The receptors and downstream signalling events via which adiponectin regulates glucose uptake in muscle have been characterized Fig. 1. High fat diet induced changes in gastric vagal afferent response to adiponectin. Author links open overlay panel Stephen J. Kentish a b Kyle Ratcliff a Hui Li a Gary A. Wittert a b c Amanda J. Page a b c. Show more. Diet-induced changes in adiponectin receptor expression in nodose ganglia NDG.
APPL1 adaptor protein containing PH domain, PTB domain, and leucine zipper motif 1 has been established as an important mediator of insulin and adiponectin signaling. Here, we investigated the influence of transgenic Tg APPL1 overexpression in mice on high-fat diet HFD-induced cardiomyopathy in mice. 10/01/2013 · The purpose of this study was to investigate the relationship between serum taurine level and serum adiponectin or leptin levels in high-fat diet-induced obesity rats. Five-week-old male Sprague–Dawley rats were randomly divided into three groups for a period of 8 weeks normal diet, N group; high-fat diet, HF group; high-fat diettaurine, HFT group. Adiponectin treatment reverses diet-induced cardiomyocyte insulin resistance. Adiponectin knockout Ad-KO mice were fed either commercial chow Chow or 60% high fat diet HFD diet at the age of 6 weeks for a period of 6 weeks. 31/05/2017 · Low levels of adiponectin APN, an adipose-derived adipokine, are associated with obesity and non-alcoholic steatohepatitis although its role in high-fat diet-induced hepatic injury and steatosis remains unclear. Here we hypothesized that APN deficiency alters fat diet-induced hepatic function. To this end, we examined the effect of.
Deshaies, Y. Xu, A. & Sweeney, G. Adiponectin corrects high fat diet-induced disturbances in muscle metabolomic profile and whole body glucose homeostasis Diabetes 2013 623:743-52. facebook. twitter. yfile. Search. site search button. Application. Apply Online to York. Faculty of Graduate Studies Events and Deadlines. Dec. 1. Sun. 27/12/2016 · Adiponectin APN, an adipose-derived adipokine, offers cardioprotective effects although the precise mechanism of action remains unclear. This study was designed to examine the role of APN in high fat diet-induced obesity and cardiac pathology. 14/08/2015 · A western diet comprised of a high fat content is a primary contributing factor for obesity which has led to extensive studies using models of high fat diet HFD to delve into the pathobiologies of obesity-related diseases. Sphingolipids are bioactive lipids which are involved in cellular signaling and regulatory functions. The current study thus aimed to examine the efficacy of adiponectin in improving testicular dysfunction in high-fat diet/streptozotocin-induced T2D mice. T2D was induced in pre-pubertal mice fed with high-fat diet for ∼10 weeks followed by single treatment of streptozotocin. 17/06/2002 · Severe diet-induced insulin resistance in KO mice. Adiponectin KO mice showed disturbed FFA catabolism and elevated plasma TNF-α concentrations in the basal state. In light of this, we challenged adiponectin KO mice with a high-fat/high-sucrose HF/HS diet.
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